Evaluating the Pulmonary Nodule With Imaging and Biomarkers
1. To improve diagnostic yield of pulmonary nodule or mass by using combined approach of
navigation bronchoscopy and EBUS.
2. To determine if characteristic features of EBUS and confocal microendoscopy exist as
well as VOC patterns in alveolar and exhaled gas that can aid in discriminating
malignant pulmonary nodule or mass from benign etiology by correlating with pathology.
3. To identify VOC patterns specific for lung cancer by correlating VOC from directly
sampled alveolar gas and exhaled breath with pathology. Exhaled breath VOC signature
may complement CT in screening population at risk.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Correlating pathology between EBUS, confocal microendoscopy and VOC patterns to aid in characterising malignant and benign etiology.
Pyng Lee, MD
National University Hospital, Singapore
Singapore: Domain Specific Review Boards