Treatment of Advanced Colorectal Cancer Patients With Hepatic Liver Metastases Using the CCR5-Antagonist Maraviroc (Phase I Maracon Trial)
- written informed consent (must be available before enrollment in the trial)
- age ≥ 18 years
- male or female patient with a history of treated metastatic stage IV colorectal
cancer with liver metastases of the primary colorectal cancer
- histologically confirmed liver metastasis of colorectal cancer with histologically
confirmed CCR5 expression in the tumor cells
- expected survival of at least three months
- Karnofsky performance status > 70 %
- patients that have received current standard treatment options (progression or
intolerance to oxaliplatin, irinotecan and 5-FU with or without treatment
combinations of cetuximab and/or bevacizumab or panitumumab)
- no chemotherapy treatment within the last three weeks
- within the last 2 weeks prior to study day 1 the following laboratory parameters,
which should be within the ranges specified (or as deemed acceptable by trial
investigator): absolute neutrophil count (ANC) ≥ 1000/mm3 (≥ 1.0 x 109/L), platelets
≥ 80.000/mm3 (≥ 80 x 109/L), creatinine Clearance limit as assessed by GFR > 60
mL/min/1.73m², ALT, AST, and total bilirubin all ≤ 5.0 x ULN
- able and willing to give valid written informed consent and to understand character
and individual consequences of the clinical trial
- if the patient is female, she must be of non-childbearing potential, or practice
- Patients with severe kidney disorders (GFR of <30 mL/min/1.73m² and diagnosed kidney
disease) or who are on hemodialysis. The patient requires concomitant chronic
treatment with systemic corticosteroids or any other immunosuppressive agents.
Topical or inhalational steroids are permitted.
- Patients taking immunomodulatory medication (Type 1 interferons).
- Use of any investigational or non-registered product (drug or vaccine) other than the
- Patients with single metastatic lesions (intent to resect the metastasis)
- Patients with metastatic colorectal cancer that have a drastic clinical progression
(e.g. from Karnofsky performance 100% to 60%) within the last six weeks before
screening cannot participate
- The patient has a history of autoimmune disease.
- The patient has a family history of congenital or hereditary immunodeficiency.
- The patient is known to be positive for Human Immunodeficiency Virus (HIV) or other
chronic infections (HBV, HCV).or has another confirmed or suspected immunosuppressive
or immunodeficient condition.
- The patient has psychiatric or addictive disorders that may compromise his/her
ability to give informed consent or to comply with the trial procedures.
- The patient has concurrent chronic severe medical problems (heart failure,
uncontrolled diabetes, bleeding disorder etc.), unrelated to the malignancy, that
would significantly limit full compliance with the study or expose the patient to
- The patient has previous or concomitant malignancies at other sites, except
effectively treated carcinoma in situ of the cervix or effectively treated malignancy
that has been in remission for over 5 years and is highly likely to have been cured.
- For female patients: the patient is pregnant or lactating.
- Women of childbearing potential: Refusal or inability to use effective means of
- History of hypersensitivity to the investigational medicinal product or to any drug
with similar chemical structure or to any excipient present in the pharmaceutical
form of the investigational medicinal product
- Participation in other clinical trials or observation period of competing trials,
- No subject will be allowed to enroll in this trial more than once.