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A Randomized Double Blind Placebo Controlled Single Institution Phase 2 Study of Metformin in Patients Undergoing Active Surveillance for Prostate Cancer.

Phase 2
18 Years
80 Years
Not Enrolling
Prostate Cancer

Thank you

Trial Information

A Randomized Double Blind Placebo Controlled Single Institution Phase 2 Study of Metformin in Patients Undergoing Active Surveillance for Prostate Cancer.

Inclusion Criteria:

- Willing and able to provide informed consent

- Men >= 18 years of age, and less than 80

- Men with biopsy proven, low-risk, localized prostate cancer (as defined below)

- Men choosing expectant management as primary treatment for prostate cancer

- Diagnostic biopsy performed within 4 months of screening visit

- Gleason score ≤ 6 in 3 cores or less with no Gleason pattern 4, less than 50% of any
core involved in cancer

- Clinical stage T1c-T2a (Initial diagnosis of T1a/T1b obtained during a TURP is not

- Serum PSA ≤10 ng/mL

- Life expectancy greater than 5 years

- Normal kidney and hepatic function as defined by the following criteria:

- Total bilirubin less than 1.5 X institutional upper limit of normal (ULN)

- AST (SGOT)/ALT(SGPT) less than 1.5 X institutional ULN

- Alkaline phosphatase less than 2 X institutional ULN

- Creatinine less than 1.4 X institutional ULN

- Able to swallow and retain oral medication

- No exposure to metformin within 12 months of randomization

- No known hypersensitivity or intolerance to metformin hydrochloride

- No condition associated with increased risk of metformin hydrochloride-associated
lactic acidosis (e.g., congestive heart failure defined as NYHA class III or IV
function status, history of acidosis of any type, or habitual intake of ≥ 3 alcoholic
beverages per day, or age greater than 80)

- English fluency allowing for patient reported outcomes completion

Exclusion Criteria:

- Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy,
oral glucocorticoids, GnRH analogues)

- Diabetes including type 1 diabetes. Patients with known type 2 diabetes are eligible
provided they have not been on metformin during the previous 12 months and are not on
any other pharmacological agents.

- Concurrent or previous use of anabolic steroids or drugs with anti androgenic
properties including 5-ARIs (dutasteride and finasteride)

- Prostate volume greater than 80 cc. (as per TRUS biopsy report)

- Prostatic surgery or procedure within 3 months of screening visit

- Severe BPH symptoms (IPSS ≥25, or ≥20 if already on α-blocker therapy)

- Other malignancies, with the exception of adequately treated nonmelanoma skin cancer,
NMIBC or other solid tumors curatively treated with no evidence of disease for ≥ 5

- Planned or concurrent participation in other interventional randomized trials
including exercise

- The presence of any other coexistent medical condition that in the opinion of the
investigator would have the potential to significantly limit adherence to medication,
or ability to absorb the medication including but not limited to psychiatric
conditions, malabsorption syndromes or severe ischemic heart disease

- Known hypersensitivity or intolerance to metformin

- Concurrent or planned participation in randomized trials of weight loss or exercise
interventions or trials targeting insulin, IGF-1 or their receptors, or PI3K

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Primary Clinical Outcome - Inhibition of Prostate Cancer

Outcome Description:

To assess the role of metformin on the inhibition of low-risk localized prostate cancer progression in men undergoing active surveillance for prostate cancer.

Outcome Time Frame:

18 months

Safety Issue:



Canada: Health Canada

Study ID:




Start Date:

January 2013

Completion Date:

October 2014

Related Keywords:

  • Prostate Cancer
  • Prostatic Neoplasms