Inclusion Criteria

Inclusion criteria

1. Histologically or clinically diagnosed with thyroid cancer

2. Eastern Cooperative Oncology Group Performance Status (ECOG-PS) 0-2

3. Adequate laboratory values/organ function tests

Exclusion criteria

Subjects with following complication or disease history

1. Brain metastasis

2. Systemic severe infection

3. Significant cardiovascular impairment

4. QTc greater than 480 milliseconds

5. Active hemoptysis

6. Bleeding or thrombotic disorders

7. Having greater than 1+ proteinuria on urine dipstick testing will undergo 24 hr urine
collection for quantitative assessment of proteiuria

8. Gastrointestinal malabsorption or any other condition in the opinion of the
investigator that might affect the absorption of E7080

9. Major surgery within 3 weeks before enrollment

10. With co-existing effusion requiring drainage