Effects of Orally Administered Beta-glucan on Leukocyte Function in Humans, a Pilot Study
The immunostimulatory properties of mushrooms have been recognized for centuries, and
"medicinal" mushrooms are still widely used in alternative medicine all over the world.
Although a number of fungal components have been implicated in these properties,
Beta-glucans have attracted the most attention. However, although Beta-glucans are widely
used as a health food supplement, their immunomodulatory effects after administration in
humans have not yet been determined.
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Tumor necrosis factor (TNF)-α secretion by ex vivo lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs)
The primary objective of the study is to evaluate the systemic effects of orally administered Beta-glucan on innate immune responses of leukocytes. The effects of Beta-glucan will be determined by measuring the ex vivo responsiveness of leukocytes to various inflammatory stimuli as a surrogate marker of the antimicrobial response
up to 21 days
Mihai Netea, MD, PhD
Radboud University Nijmegen Medical Centre, The Netherlands
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)