Stimulation of the Cervical Sympathetic Ganglion for Treatment of Asthma.
Asthma is a chronic inflammatory disorder of the airways characterized by shortness of
breath, wheezing, cough, and fatigue. Some people suffer from sudden worsening of asthma
symptoms despite being treated with medications. When people have asthma attacks the muscle
tissue in the airway contracts causing the airway to narrow and decreasing the ability for
the person to breathe.
Neurological pacemakers are FDA approved devices that stimulate nerves in the body and have
been used for the treatment of many disorders such as Parkinson's, epilepsy, chronic pain
and urinary incontinence. Recent animal studies have shown that stimulating (activating a
nerve) the carotid sheath area (located in the neck) can cause the rapid relaxation of the
muscles which contract during an asthma attack. This approach has also been successfully
used in patients at an emergency room when they came in with a severe asthma attack.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Evaluate if neurostimulation of stellate ganglion modulates airway hyperresponsiveness to bronchoprovocation testing. Comparison of FEV1 drop before and after neurostimulation testing will be primary outcome measure
To determine whether neurostimulation of the stellate ganglion modulates airway hyperresponsiveness to bronchoprovocation testing in asthmatics
60 minutes post treatment
Jonathan P Parsons, M.D.
Ohio State University
United States: Institutional Review Board
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