Inclusion Criteria:

1. Age 18-70 years.

2. Performance status ECOG 0-2.

3. Clinically and / or radiologically proven stage IV or recurrent HER2 negative breast
cancer.

4. At least one tumor lesion accessible for biopsy. This lesion may not have been
treated previously with irradiation.

5. Clinically and/or radiographically documented measurable disease according to RECIST
v1.1 criteria. At least one site of disease must be unidimensionally measurable as
follows:

1. CT-scan, physical exam ≥ 10 mm} Chest X-ray ≥ 20 mm }see Eisenhauer et al. for
more details

2. Lymph node short axis ≥ 15 mm }

3. All radiology studies must be performed within 28 days prior to registration (35
days if negative).

6. Adequate bone-marrow, hepatic and renal function defined as laboratory tests within 7
days prior to enrollment:

1. Haematology: Absolute granulocytes > 1.5 x 109/L Platelets > 100 x 109/L

2. Biochemistry:Bilirubin within normal limits Serum creatinine within normal
limits

7. APTT and INR within normal limits within 7 days prior to enrollment.

8. Adequate cardiac function with Left Ventricular Ejection Fraction (LVEF) within
normal limits determined by echocardiogram or MUGA within 28 days prior to
inclusion.

9. Written informed consent must be given.

Exclusion Criteria:

1. Previous systemic treatment for MBC.

2. Major surgery less than 28 days prior to enrollment.

3. Concurrent malignancy of any site, except adequately controlled limited basal cell
carcinoma or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix.

4. Bleeding diathesis, history of thromboembolic disease, or ongoing treatment with
warfarin, heparin analogs or antiplatelet drugs.

5. Major cardiac comorbidity.

6. Previous treatment with bevacizumab.

7. Previous allergic reaction to taxane analogs.

8. Ongoing pregnancy or lactation.

9. Any psychological, familial, sociological or geographical condition potentially
hampering compliance with the study protocol and follow-up schedule; those conditions
should be discussed with the patient before registration in the trial.