Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer
Rectal cancer is a common form of cancer, and the treatment stratification depends on tumour
and nodal stage as determined on MRI. Unfortunately, the information provided by standard
T2-weighted MRI is not sufficient to accurately assess nodal involvement and tumour response
after neo-adjuvant chemoradiotherapy. Additional functional information is required for
reliable (re)staging. Diffusion-weighted imaging and gadofosveset-enhanced MRI are two new
imaging techniques that have all shown great potential in rectal cancer staging. In order to
provide definite evidence there is a need for a multicenter study with a large patient
Observational Model: Cohort, Time Perspective: Prospective
Diagnostic performance of the techniques under investigation
Techniques under investigation are diffusion-weighted imaging for tumour response assessment and gadofosveset-enhanced MRI for nodal assessment, compared to standard T2-weighted MRI.
Regina Beets-Tan, Prof. MD.
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)