Inclusion Criteria:

- Subjects with histological proven esophageal carcinoma receiving ECX (epirubicine,
cisplatin, capecitabine) (Arm I), patients receiving CAPOX (oxaliplatin,
capecitabine) (Arm II).

- Age ≥ 18 years and < 70 years.

- Platinum-based chemotherapy naïve for at least 6 months.

- Subjects with at least one evaluable lesion.

- WHO Performance Status of 0 or 1.

- Female participants should be of non-child bearing potential either physiologic or by
using adequate contraception, have a negative serum pregnancy test, and refrain from
breast feeding.

- Written informed consent.

Exclusion Criteria:

- Known or suspected allergy or hypersensitivity to indomethacin or any agent given in
association with this trial, in particular subjects who have a history of severe
hypersensitivity reactions to anti-emetics (5-HT3 antagonists, metoclopramide or
corticosteroids) and acetylsalicylic acid or other prostaglandin synthethase
inhibitors.

- Symptomatic brain or meningeal tumors

- Subjects with seizure disorder requiring medication (such as corticosteroids or
anti-epileptics).

- Any of the following concurrent severe and/or uncontrolled medical conditions which
could compromise participation in the study:

- Uncontrolled high blood pressure, history of labile hypertension, or history of poor
compliance with an antihypertensive regimen

- Unstable angina pectoris

- Symptomatic congestive heart failure NYHA class ≥ 3 (see appendix 13.6)

- Myocardial infarction ≤ 6 months prior to randomization

- Serious uncontrolled cardiac arrhythmia

- Active peptic ulcer disease, gastritis, inflammatory bowel disease.

- History of active gastro-intestinal bleeding

- History of cerebro-vascular disease

- Bleeding diathesis

- Chronic renal disease defined as GFR (MDRD) <60 ml/min

- Absolute Neutrophil Count (ANC) < 1.5 x 109/L (< 1500/mm3)

- Platelets (PLT) < 100 x 109/L (< 100,000/mm3)

- Hemoglobin (Hgb) < 6.0 mmol/l (patients may be transfused to achieve adequate Hb)

- Partial thromboplastin time (PTT) > 1,5 x ULN

- Serum bilirubin > 1.5 ULN

- Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) > 3.0
x ULN (> 5 x ULN if liver metastases present)

- Patients who are unable or unwilling to comply with the protocol

- Chronic treatment with a corticosteroid agent (nebulized corticosteroids are allowed)

- Patients who received radiation therapy within 4 weeks of the start of the study

- Patients who received an experimental agent less than 4 weeks before start of the
study.

- Patients who used Omega-3/omega-6 containing products, including fish oil products
less than 2 weeks before start of the study.

- Chronic use of NSAID's and/or acetylsalicylic acid and/or other prostaglandin
synthethase inhibitors.

- Use of anticoagulant therapy