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Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

50 Years
79 Years
Open (Enrolling)
Mesothelioma, Lung Cancer

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Trial Information

Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

Inclusion Criteria:

- Women or men age 50 to 79 years

- history of exposure to asbestos at work and one or more of the following:

- lung cancer risk ≥2% over 3 years or

- asbestosis or pleural plaques on a chest x-ray or

- abnormal auto-antibodies level using the EarlyCDT test

- Capable of providing informed consent for screening procedures (low dose spiral CT,
lung function, blood biomarkers).

Exclusion Criteria:

- Any medical condition, such as severe heart disease (e.g. unstable angina, chronic
congestive heart failure), acute or chronic respiratory failure, or any disorder,
that in the opinion of the physician unlikely to benefit from screening due to
shortened life-expectancy from co-existing illnesses

- Have been previously diagnosed with mesothelioma

- Have had other cancer within the past 5 years with the exception of the following
cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ
(CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must
have ended >6 months before registration into this study

- Pregnancy

- Unwilling to have a low dose CT scan of chest

- Unwilling to sign a consent

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Stephen Lam

Investigator Role:

Principal Investigator

Investigator Affiliation:

British Columbia Cancer Agency


Canada: Ethics Review Committee

Study ID:




Start Date:

October 2012

Completion Date:

December 2014

Related Keywords:

  • Mesothelioma
  • Lung Cancer
  • Mesothelioma
  • Lung Cancer
  • Early Detection
  • Lung Neoplasms
  • Mesothelioma