Inclusion Criteria:

- Gleason Score 7 with PSA < 20 ng/ml and T1-2b exam, or

- Gleason Score 8-10 with less than 50% cores positive, PSA ¬¬< 10 ng/ml and T1 exam,
or

- PSA 10.1-30 ng/ml with GS < 7 and T1 exam, or

- Clinical T3 with Gleason Score < 7 and PSA < 10 ng/ml. T3 clinical stage may be based
on exam or imaging (MRI, CT, ultrasound) prior to entry

- Serum testosterone >150 ng/dl prior to start of androgen deprivation

- CBC with differential with adequate bone marrow function defined as follows:

- Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3, Platelets > 100,000/µL and
Hemoglobin > 9g/dL

- Serum potassium > 3.5 mEq/L

- Serum albumin > 3.0 g/dl

- Total bilirubin < 1.5 X of institutional upper limit of normal (ULN)

- AST(SGOT)/ALT(SGPT) < 1.5 X ULN

Exclusion Criteria:

- Bone or soft tissue metastasis, including lymph nodes

- Prior therapy for prostate cancer

- Previous malignancy within 3 years other than non-melanomatous skin cancer and
non-muscle invasive bladder cancer

- Uncontrolled hypertension

- History of gastrointestinal disorders that may interfere with the absorption of study
drug (including gastric bypass surgery)

- Significant concurrent medical condition that would make prednisone/prednisolone use
contraindicated