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Phase II Clinical Study of Metronomic Oral Cyclophosphamide in Elderly and/or Pre-treated Patients With Advanced Sarcomas

Phase 2
21 Years
Open (Enrolling)

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Trial Information

Phase II Clinical Study of Metronomic Oral Cyclophosphamide in Elderly and/or Pre-treated Patients With Advanced Sarcomas

Eligible patients will receive continuous metronomic oral cyclophosphamide at a dose of 50mg
daily. Tumor assessments will be performed at baseline and every 6 weeks thereafter to
assess response and disease progression. Toxicity will be monitored throughout treatment.
The study's primary end point is defined as clinical benefit rate (CBR) at 12 weeks as a
measure of disease control. The study is designed to distinguish a favorable true PFR of 40%
from a null rate of 20% [Van Glabbeke et al. EJC 2002]. With a CBR of 40%, metronomic oral
cyclophosphamide at this dose and schedule in this patient population will be considered
worthy of further evaluation.

Inclusion Criteria:

Participants must meet the following criteria on screening examination to be eligible to
participate in the study:

1. Participants must have histologically or cytologically confirmed, metastatic and/or
unresectable high grade sarcoma for which standard multi-modality curative therapies
do not exist or are no longer effective. Patients with low grade sarcoma need to
additionally demonstrate disease progression in the last 6 months prior to study

2. Age > 21 years

3. Prior anti-sarcoma chemotherapy

- Participants who are 21 to 64 years of age at the time of study entry must have
received at least one line of established chemotherapy, if such treatment
exists; or refused such treatment, which includes either an anthracycline and/or
ifosfamide. Patients whose sarcomas do not have known established therapy are
eligible for this study without the requirement of a prior therapy.

- Participants > 65 years of age at the time of study entry are eligible for this
study without the requirement for prior treatment

4. ECOG performance status 0-3 (see Annex A)

5. Measurable disease outside of a prior irradiated area as defined by RECIST 1.1
guidelines. A lesion in a previously irradiated area is not eligible for measurable
disease unless there is objective evidence of progression of the lesion prior to
study enrollment

6. No limit to number of prior chemotherapies or biologics

7. Participants must have normal organ function as defined below:

- Hemoglobin > 10g/dL

- Absolute neutrophil count (ANC) > 1500/mm3

- Platelet count > 75,000/mm3

- Total bilirubin < 1.5 times institutional upper limits or normal (ULN)

- AST/ALT < 3 times ULN (< 5 times ULN if hepatic involvement is present)

- Creatinine < 1.5 times ULN. If creatinine is > 1.5 times ULN, a calculated
creatinine clearance time (CCT) should be performed and patient would be
eligible for study if the calculated CCT is > 10 mL/min.

[NB: Glomerular filtration rate (GFR) = [(140 - age) x weight [kg] x 1.22 ] / (serum
creatinine [umol/L]. In women, multiply this result by 0.85

8. Resolution, or return to baseline of all clinically significant toxicities related to
prior therapies

9. Patients must be suitable for oral drug administration

10. Willingness to use effective means of birth control throughout the duration of
clinical study and for at least 3 months after completion of study drug

11. Women of childbearing potential must have a negative pregnancy test performed within
7 days of the start of study drug administration

12. Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Participants who exhibit any of the following conditions at screening will not be eligible
for admission into the study.

1. Patients diagnosed with gastrointestinal stromal tumor (GIST)

2. Participants who have had systemic anti-cancer therapy within 3 weeks of study entry
(8 weeks for nitrosoureas or mitomycin C)

3. Palliative radiotherapy or major surgery within 3 weeks of study entry

4. Concurrent use of any other anti-cancer therapies or study agents

5. Symptomatic or uncontrolled brain or central nervous system metastases

6. Participants may not be receiving any other concomitant investigational agents

7. Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

8. Individuals with a history of a different malignancy, other than cervical cancer in
situ, basal cell or squamous cell carcinoma of the skin, are ineligible, except if
they have been disease-free for at least 5 years, and are deemed by the investigator
to be at low risk for recurrence of that malignancy OR other primary malignancy is
neither currently clinically significant nor requiring active intervention.

Type of Study:


Study Design:

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Clinical benefit as defined by the composite of complete response (CR), partial response (PR) and stable disease (SD) lasting > 12 weeks per RECIST 1.1 as a measure of disease control

Outcome Time Frame:

24 months

Safety Issue:


Principal Investigator

Richard Quek

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Centre, Singapore


Singapore: Health Science Authority

Study ID:




Start Date:

August 2012

Completion Date:

August 2015

Related Keywords:

  • Sarcoma
  • Sarcoma