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Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.


N/A
4 Years
N/A
Open (Enrolling)
Both
Healthy Volunteers, Children With HSP, Subject With Allergy, Lymphoma

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Trial Information

Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.


This study should thus finally provide answers to 5 questions which are currently
un-addressed:

- How the 3'RR alleles are linked to IgG allotypes and corresponding IgH haplotypes?

- Is there a physiological link between 3'RR alleles and production of the various Ig
classes and sub-classes?

- Is the 3'RR polymorphism connected with the risk of more severe forms of allergic
diseases?

- Is the 3'RR polymorphism connected with the risk of occurrence and/or severe evolution
of HSP?

- Is the oncogenicity of translocations affecting the IgH locus connected to the strength
of the 3'RR allelic variants?


Inclusion Criteria:



- Healthy Volunteers:

Age ≥ 18 and < 50 years No history of allergy, haematological malignancies or immune
diseases

- Subjects with allergy:

- Children:

Age ≥ 4 and < 18 years Clinical history supporting the diagnosis of severe food allergy
Peanut specific IgE (Arah2) -Adults: Age > 18 and < 60 years History of severe reaction
after antigenic challenge Anaphylactic shock already experienced Specific IgE or positive
BAT Positive prick tests

- subject with HPS:

- Children:

Age ≥ 4 and < 18 years Henoch Schonlein Purpura (HSP) documented by Ankara 2008 criteria

-Adult: Henoch Schonlein Purpura(HSP) with renal involvement Adults ≥ 18 years,

Exclusion Criteria:

- subject with allergy or subject with Henoch Schonlein Purpura(HSP): known pregnancy
patient under guardianship

- Healthy Volunteers:

Allergy known pregnancy patient under guardianship

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

the percentage of allele B

Outcome Description:

A comparison will be made of the percentage of allele B between healthy volunteers and the three cohorts of subjects with various diseases: (1) lymphoma (lymphoma-proliferation with chromosome 14 translocation ), (2) Henoch-Schonlein purpura HSP (3), allergy (peanut and Hymenoptera venom)

Outcome Time Frame:

one day

Safety Issue:

No

Principal Investigator

Michel COGNE, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Limoges UH

Authority:

France: Agence Nationale de Sécurité du Médicament et des produits de santé

Study ID:

I12002 PRIERR

NCT ID:

NCT01715623

Start Date:

October 2012

Completion Date:

April 2015

Related Keywords:

  • Healthy Volunteers
  • Children With HSP
  • Subject With Allergy
  • Lymphoma
  • polymorphism
  • serum Ig
  • Lymphoma

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