Acute Effects of Exercise on the Cortical Silent Period in Prostate Cancer Patients
Inclusion Criteria:
- Histologically confirmed PCa;
- > 6 months post curative therapy for PCa (radical prostatectomy or radiation therapy)
with or without adjuvant androgen deprivation therapy;
- Willing and able to provide informed consent;
- If metastatic disease is present, they are asymptomatic; v) n
- No contraindications to exercise
Exclusion Criteria:
- Severe coronary artery disease (Canadian Cardiovascular Society class III or
greater);
- Significant congestive heart failure (New York Heart Association class III or
greater);
- Uncontrolled pain;
- Neurological or musculoskeletal co-morbidity inhibiting exercise;
- Diagnosed psychotic, addictive, or major cognitive disorders or are currently or have
a history of using psychotropic medication (anti-depressants, anti-anxiety,
anti-psychotics, benzodiazepines, etc);
- Contraindications to magnetic exposure (surgical clips in the brain; cardiac pace
maker or valves; cochlear implants; metal rods, plates, screws in head;
shrapnel/metal fragments in head/eyes; dentures);
- Prior history of seizures or diagnosis of epilepsy;
- Left-hand dominant; and
- No more than two of the following Coronary Risk Factors as defined by the American
College of Sports Medicine[41, 42]:
- Family history of coronary disease, cigarette smoking, hypertension (Systolic
Blood Pressure (SBP) > 140 mmHg; Diastolic Blood Pressure (DBP) > 90 mmHg),
known dyslipidemia, known impaired fasting, glucose (>110 mg/dL), obesity (BMI >
30 kg/m2 or waist circumference > 102cm), or physically inactive (<150 min of
moderate intensity physical activity per week)