Inclusion Criteria:

1. female

2. Primary invasive breast cancer pathologically approved by core needle or open biopsy

3. Patients must have undergone standard surgery for primary breast cancer as shown in
the following:

- mastectomy

- breast conservation surgery followed by whole breast radiation

- axillary dissection or sentinel node biopsy

4. Need adjuvant chemotherapy after surgery

5. Patients taking neo-chemotherapy are eligible

6. Patients with synchronous bilateral cancers are eligible on the condition that If one
side is IDC and the other side is DCIS, the IDC side should be of the ER and/or PR
positive phenotype and IF two sides are both IDC, they must be ER and/or PR positive
phenotype at the same time

7. Hormone receptor positive (≥＋) is defined as detecting ER or PR expression at any
time is eligible. The situation of only PR positive and ER negative is eligible, too

8. Based on the study objective, all patients are required to be premenopausal as
defined by

- menstruating actively

- less than 6 months since last menstrual period (LMP), or patients younger than
40 years of age who became amenorrheic not more than 1 year if the serum free
E2、FSH and LH level was premenopausal (according to the reference value of local
center).

- had previous hysterectomy with one or both ovaries left intact are eligible if
the serum free E2、FSH and LH level are premenopausal (according to the reference
value of local center).

9. patients must have an ECOG performance status of 0 or 1 (0-fully active, able to
carry on all pre-disease performance without restriction, 1-restricted in physical
strenuous actively but ambulatory)

10. leucocyte count must be ≥ 3.0*10^9/L and platelet count must be ≥ 100*10^9/L

11. AST/SGOT or ALT/AGPT must be < 3 times the ULN

12. serum creatinine must be < 2 times the ULN

13. pregnancy testing is negative and are willing to do contraception during the
treatment period

Exclusion Criteria:

1. patients with metastatic malignant tumor

2. previous history of asynchronous bilateral breast cancer

3. any previous malignancy in the past 5 years, except for those treated with curative
intent, such as carcinoma in situ of the cervix, squamous carcinoma of the skin or
basal cell carcinoma of the skin

4. any non-malignant systemic disease which interfere long time follow up

5. history of medical ovarian ablation therapy

6. severe live dysfunction, Child－Pugh is grade C

7. Severe renal dysfunction

8. Occult breast cancer

9. severe heart dysfunction, heart functional classification is above Class III