Diagnostic Value of Diffusion Weighted Imaging in Detection of Recurrent Disease in Cervical and Endometrial Cancer Treated With Curative Surgery
Endometrial and cervical cancers are one of the most common malignancies seen in female
genital tract. Although, surgical resection is the treatment of choice for both, adjuvant or
neo-adjuvant chemotherapy or radiotherapy and curative radiotherapy are alternative
treatment options depending on the stage.
Identification of recurrent disease in early phases carries a primary importance on the
Diffusion-weighted MRI (DWI), a new technique recently started to be performed in body
imaging has potential ability to distinguish recurrent disease from normal tissue or
fibrosis. Our aim in this study is to investigate the diagnostic impact of DWI in detection
of recurrence rate in patients treated with curative surgery in endometrial and cervical
All patients who had curative surgery due to endometrial or cervical cancer will be included
to the study. Patients will be examined with DWI in addition to routine sequences including
contrast enhanced dynamic studies. The sensitivity, specificity, accuracy as well as
positive and negative predictive values of the study will be investigated from the data
derived from DWI studies and will be correlated with data obtained by conventional
radiologic, nuclear imaging studies including PET-CT, as well as pathologic verifications
during follow-up period.
Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Diagnostic
Investigation of the diagnostic value of DWI in detection of recurrence rate in patients treated with curative surgery in endometrial and cervical cancer.
Postoperative recurrent disease is usually investigated with physical examination, ultrasonography, computed tomography (CT), conventional magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) with different sensitivity and specificities. However, radiologists experience difficulty in detection of small recurrent active tumors with anatomically-based radiologic modalities like CT or conventional MRI in patients treated with hysterectomy. Furthermore, effects of adjuvant therapies or fibrosis developed following surgery could mask or even mimic the recurrent tumor. Our aim in this study is to investigate the diagnostic impact of DWI in detection of recurrence rate in patients treated with curative surgery in endometrial and cervical cancer.
Gürsel Savcı, Prof.
Uludag University Faculty of Medicine
Turkey: Ethics Committee