Inclusion Criteria:

- Stage IV or locally advanced cancers that are refractory to standard therapy for
which no alternative therapies with proven survival advantage are available

- At least 1 lesion amenable for an outpatient biopsy; this should be a cutaneous or
palpable metastatic site or a deeper site accessible by image-guided biopsy that is
deemed safe to access by the treating physicians and interventional radiologists;
patients without accessible lesions for biopsy but with prior tissue available from
metastatic disease would be eligible at the investigator's discretion

- NY-ESO-1 positive malignancy by immunohistochemistry (IHC) utilizing commonly
available NY-ESO-1 antibodies

- Human leukocyte antigen (HLA)-A*0201 (HLA-A2.1) positivity by molecular subtyping

- Life expectancy greater than 3 months assessed by a study physician

- A minimum of one measurable lesion defined as:

- Meeting the criteria for measurable disease according to Response Evaluation
Criteria in Solid Tumors (RECIST)

- For patients with skin metastases, lesions selected as non-completely biopsied target
lesion(s) that can be accurately measured and recorded by color photography with a
ruler to document the size of the target lesion(s)

- No restriction based on prior treatments

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1

- Absolute neutrophil count >= 1.5 x 10^9 cells/L

- Platelets >= 100 x 10^9/L

- Hemoglobin >= 10 g/dL

- Aspartate and alanine aminotransferases (AST, ALT) =< 2.5 x upper limit of normal
(ULN) (=< 5 x ULN, if documented liver metastases are present)

- Total bilirubin =< 2 x ULN (except patients with documented Gilbert's syndrome)

- Creatinine < 2 mg/dl (or a glomerular filtration rate > 60 mL/min)

- Must be willing and able to accept at least two leukapheresis procedures

- Must be willing and able to accept at least two tumor biopsies

- Must be willing and able to provide written informed consent

Exclusion Criteria:

- Previously known hypersensitivity to any of the agents used in this study

- Received systemic treatment for cancer, including immunotherapy, within one month
prior to initiation of dosing within this protocol; however, cell harvesting by
leukapheresis may be performed before one month from prior therapy if the study
investigators consider that it will not have a detrimental impact on the generation
of the two cell therapies in this protocol

- History of, or significant evidence of risk for, chronic inflammatory or autoimmune
disease (eg, Addison's disease, multiple sclerosis, Graves disease, Hashimoto's
thyroiditis, inflammatory bowel disease, psoriasis, rheumatoid arthritis, systemic
lupus erythematosus, hypophysitis, pituitary disorders, etc.); patients will be
eligible if prior autoimmune disease is not deemed to be active (example: fibrotic
damage of the thyroid after thyroiditis or its treatment, with stable thyroid hormone
replacement therapy); vitiligo will not be a basis for exclusion

- History of inflammatory bowel disease, celiac disease, or other chronic
gastrointestinal conditions associated with diarrhea or bleeding, or current acute
colitis of any origin

- Potential requirement for systemic corticosteroids or concurrent immunosuppressive
drugs based on prior history or received systemic steroids within the last 4 weeks
prior to enrollment (inhaled or topical steroids at standard doses are allowed)

- Human immunodeficiency virus (HIV) seropositivity or other congenital or acquired
immune deficiency state, which would increase the risk of opportunistic infections
and other complications during chemotherapy-induced lymphodepletion; if there is a
positive result in the infectious disease testing that was not previously known, the
patient will be referred to their primary physician and/or infectious disease
specialist

- Hepatitis B or C seropositivity with evidence of ongoing liver damage, which would
increase the likelihood of hepatic toxicities from the chemotherapy conditioning
regimen and supportive treatments; if there is a positive result in the infectious
disease testing that was not previously known, the patient will be referred to their
primary physician and/or infectious disease specialist

- Dementia or significantly altered mental status that would prohibit the understanding
or rendering of informed consent and compliance with the requirements of this
protocol

- Clinically active brain metastases; radiological documentation of absence of active
brain metastases at screening is required for all patients; prior evidence of brain
metastasis successfully treated with surgery or radiation therapy will not be
exclusion for participation as long as they are deemed under control at the time of
study enrollment

- Pregnancy or breast-feeding; female patients must be surgically sterile or be
postmenopausal for two years, or must agree to use effective contraception during the
period of treatment and 6 months after; all female patients with reproductive
potential must have a negative pregnancy test (serum/urine) within 14 days from
starting the conditioning chemotherapy; the definition of effective contraception
will be based on the judgment of the study investigators

- Since IL-2 is administered following cell infusion:

- Patients will be excluded if they have a history of clinically significant
electrocardiogram (ECG) abnormalities, symptoms of cardiac ischemia or
arrhythmias and have a left ventricular ejection fraction (LVEF) < 45% on a
cardiac stress test (stress thallium, stress multigated acquisition scan [MUGA],
dobutamine echocardiogram, or other stress test)

- Similarly, patients who are 50 years old with a baseline LVEF < 45% will be
excluded

- Patients with ECG results of any conduction delays (PR interval > 200 ms,
corrected QT interval [QTC] > 480 ms), sinus bradycardia (resting heart rate <
50 beats per minute), sinus tachycardia (heart rate [HR] > 120 beats per minute)
will be evaluated by a cardiologist prior to starting the trial; patients with
any arrhythmias, including atrial fibrillation/atrial flutter, excessive ectopy
(defined as > 20 premature ventricular contractions [PVCs] per minute),
ventricular tachycardia, 3rd degree heart block will be excluded from the study
unless cleared by a cardiologist

- Patients with pulmonary function test abnormalities as evidenced by a forced
ejection volume in 1 second (FEV1)/forced vital capacity (FVC) < 70% of
predicted for normality will be excluded