Inclusion Criteria:

- Patients must have biopsy-confirmed non-hematological malignancy

- Patients must be scheduled to receive cytotoxic chemotherapy (adjuvant or metastatic
setting), excluding immunotherapy

- Patients must be of age >=18 years.

- Patients must have an absolute lymphocyte count >= 1,000/mcL immediately prior to
influenza vaccination

- Ability of the patient (or legally authorized representative if applicable) to
understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients who have already received the influenza vaccine during the season in which
they are considered for eligibility will be excluded

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to the influenza vaccine or egg allergies

- Previous history of Guillian-Barre syndrome within the previous 6 weeks to influenza
vaccination

- Patients must not be receiving chronic steroid therapy, defined as >= 14 days, unless
used as part of a chemotherapy regimen

- Patients must not be on any other agents that can suppress the immune system

- Planned concurrent therapy with radiation

- Uncontrolled illness at time of enrollment or influenza vaccination including, but
not limited to, ongoing or active febrile illness

- Psychiatric illness/social situations that would limit compliance with study
requirements

- Known immunosuppression eg. history of organ transplantation or known human
immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy
are ineligible because they may not be able to mount an appropriate immune response

- History of influenza-like illness, defined as a temperature > 37.8 degree C with
cough or sore throat starting October 1, 2011 throughout the duration of the study

- Patient may not be scheduled to receive chemotherapy on a weekly basis.