A Multicentral Prospective Study on Prediction of Malignant Progression of Oral Epithelial Dysplasia With p16 Methylation
Background:Oral epithelial dysplasia (OED) is one of the common precancerous lesions among
Chinese adults. To investigate the clinical predictive value of p16 methylation diagnostic
reagents in the early diagnosis of oral cancer, the investigators carried out the
prospective multi-center double-blind cohort study.
Methods:180 patients with histologically confirmed mild or moderate OED were included in the
present study. The investigators using p16 methylation diagnostic reagents to analysis of
the p16 methylation status in these patients. Building two follow-up queue by p16-methylated
and p16-unmethylated. The Statistical analysis used SAS6.12 software. All P-values were
two-sided. P<0.05 was considered to test for statistical significance difference.
Observational Model: Cohort, Time Perspective: Prospective
Dajun Deng, MD
China: Beijing Municipal Science and Technology Commission