Inclusion Criteria:

- Patients smokers (= 10 cigarettes per day in the last year)

- Affected by a chronic obstructive pulmonary disease.

- Presenting a recent exacerbation having led to at least a 24-hour hospitalization in
pneumology or intensive care unit.

- Inclusion during hospitalization.

- Motivated to quit smoking

- Able to understand the information and give a written consent.

- Available for a follow-up of 1 year.

Exclusion Criteria:

- Refusal or unable to consent.

- Unaffiliated or not entitled to the National Health Insurance Coverage.

- Absence of a chronic obstructive pulmonary disease according to the criteria ATS /
ERS.

- presenting a contraindication to the pharmacotherapy (i.e. the active substance:
tartrate of varénicline or one of the excipients)

- actively participating in other smoking cessation trials.

- Pregnancy: declared or planned in 14 months.

- breastfeeding.

- Women old enough to procreate without reliable contraception.

- History of anorexia nervosa or bulimia.

- History of a severe depression and having required a medicinal treatment in 5 years.

- History of 2 or several episodes of severe depression and having required a medicinal
treatment.

- Personal or family History of suicide attempt.

- History or current presence of dementia, a bipolar disease, a psychosis, a panic
attack.

- Taken by psychotropic medicines

- Use of marijuana or other frorms of tobacco during the study.

- Use of other stimulant drugs (ephedrine, phenylephrine) or appetite suppressants
during the study.

- Life expectancy of ≤ 12-months (ex: patients affected by a chronic disease in
terminal phase).