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Phase 1 Study of Efficacy of Combined Metformin-letrozole in Comparison With Bilateral Ovarian Drilling in Clomiphene-resistant Infertile Women With Polycystic Ovarian Syndrome


Phase 1
18 Years
35 Years
Not Enrolling
Female
Focus of Study

Thank you

Trial Information

Phase 1 Study of Efficacy of Combined Metformin-letrozole in Comparison With Bilateral Ovarian Drilling in Clomiphene-resistant Infertile Women With Polycystic Ovarian Syndrome


Inclusion Criteria:



- polycystic ovary syndrome

- infertility

- clomiphene citrate resistance

Exclusion Criteria:

- women with other causes of infertility as male factor or tubal factor, those with
endocrine disorders as thyroid dysfunction and hyperprolactinemia women who received
hormonal treatment or ovulation induction drugs 3 months prior to the study

- pregnancy during follow up

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

hormonal and metabolic changes

Outcome Time Frame:

6 months

Safety Issue:

No

Authority:

Egypt:Zagazig University

Study ID:

elsharkwy t

NCT ID:

NCT01693289

Start Date:

January 2012

Completion Date:

July 2012

Related Keywords:

  • Focus of Study
  • Metformin
  • letrozole
  • ovarian drilling
  • clomiphene resistance
  • polycystic ovary.
  • Polycystic Ovary Syndrome

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