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Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery


N/A
20 Years
75 Years
Open (Enrolling)
Both
Motor Evoked Potential Monitoring, General Anesthesia, Neurosurgery, Brain Tumor, Spine Tumor, Cerebral Aneurysm

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Trial Information

Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery


Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce
neural damage during neurosurgery.

As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial
NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is
preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in
clinical use. But there have been no reports about the effect of changing NMB agent on
efficacy of MEP monitoring.

Therefore, the investigators performed a randomized controlled trial to evaluate the effect
of changing NMB agent on the variability of MEP amplitude during neurosurgery.


Inclusion Criteria:



- Adult patients undergoing neurosurgery with intraoperative motor evoked potential
monitoring

Exclusion Criteria:

- Patients who can not undergo motor evoked potential monitoring due to central or
peripheral neuromuscular disease (e.g. Cerebral palsy, Myasthenia gravis, Acute
spinal injury, neurologic shock)

- Patients with hepatic or renal disease with altered metabolism of vecuronium

- Patients with medication which influence the metabolism of vecuronium (e.g. calcium
channel blocker, aminoglycoside antibiotics, Lithium, MgSO4)

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)

Outcome Measure:

MEP amplitude

Outcome Description:

intraoperative motor evoked potential monitoring amplitude

Outcome Time Frame:

15 min after anesthetic induction

Safety Issue:

No

Authority:

South Korea: Institutional Review Board

Study ID:

2012-05-090-001

NCT ID:

NCT01690364

Start Date:

July 2012

Completion Date:

June 2013

Related Keywords:

  • Motor Evoked Potential Monitoring
  • General Anesthesia
  • Neurosurgery
  • Brain Tumor
  • Spine Tumor
  • Cerebral Aneurysm
  • Motor evoked potential monitoring
  • General Anesthesia
  • Neurosurgery
  • Cisatracurium
  • Vecuronium
  • Aneurysm
  • Brain Neoplasms
  • Spinal Cord Neoplasms
  • Intracranial Aneurysm

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