Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce
neural damage during neurosurgery.
As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial
NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is
preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in
clinical use. But there have been no reports about the effect of changing NMB agent on
efficacy of MEP monitoring.
Therefore, the investigators performed a randomized controlled trial to evaluate the effect
of changing NMB agent on the variability of MEP amplitude during neurosurgery.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
intraoperative motor evoked potential monitoring amplitude
15 min after anesthetic induction
South Korea: Institutional Review Board