Inclusion Criteria:

1. Voluntary and sign the informed consent form; 2) Age 18-70 years old, male or female;
3) histologically proved to be keratinizing carcinoma or non-keratinizing carcinoma;
4) nasopharyngeal darcinoma 2010 UICC staging III-IV A, IV B; 5) measurable Primary
tumors; 6) karnofsky score≥70; ECOG≥2; 7) Expected survival≥6 months; 8) Women in
productive age should guarantee use contraceptives during study period; 9)
Hemoglobin(HGB) ≥100g/L, white blood cell(WBC) ≥4×109 /L，Platelet（PLT）≥100×109 /L.（or
white blood cell and platelet not less than our hospital's Normal lowest index）; 10)
liver function: Alanine amino transferase (ALAT), aspartate aminotransferase (ASAT)
<1.5 times the upper limit of the normal index; total bilirubin<1.5×ULN; 11) liver
function: serum creatinine<1.5×ULN; 12) do not have severe complication, such as
Hypertensio, Diabetes and History of mental illness; 13) this treatment is First
treatment process (do not have a H&N Radiation history; do not have a history of
Concurrent chemoradiotherapy; do not have chemotherapy history in 3 months.

Exclusion Criteria:

1. Have a distant metastasis; 2) The primary focal tumors or lymph node already had a
surgical treatment (except for biopsy); 3) Already had a radiotherapy for primary
focal or lymph node; 4) Patient who received the the epidermal growth factor targeted
therapy; 5) The primary focal had received chemoradiotherapy or immunotherapy; 6)
Patient who suffered from other malignant tumor (except for cured basal cell
carcinoma or carcinoma in situ of cervix); 7) Subject who have taken other drug test
in 1 month; 8) Peripheral Neuropathy> level; 9) pregnant woman or Lactating Women and
Women in productive age who refuse take contraception in observation period; 10)
subject with a severe allergic history or idiosyncratic; 11) subject with severe
pulmonary and cardiopathic disease history; 12) refuse or incapable to sign the
informed consent form of participating this trial; 13) drug abuse or alcohol
addicted; 14) subject with a Personality or psychiatric diseases, people with no
legal capacity or people with limited capacity for civil conduct.