MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage
In this study we want to investigate the ability of MRI to identify underlying pathology
(tumor or vascular malformations) in acute patients admitted with intracerebral hemorrhage
(ICH). Today MRI-scan is normally done 3-4 weeks after symptom onset but very little is
known about the early use of MRI to detect underlying pathology. This would allow an early
intervension and less uncertainty for the patients.
We further want to investigate the metabolic penumbra-zone surrounding the hematoma. It is
the current perception in the litterature that this zone represent a metabolic zone marked
by apoptosis and inflammation rather than ischemia.
We are planning to:
When patients arrive in our stroke department they will within 7 hours be subject to MRI
scan with the protocoled sequences. Standard sequences: Axial T2, axial DWI, Sagittal T1, T2
flair og axial GRE-sequence.
Susceptibility weighted imaging (SWI)
Chemical Shift Imaging (CSI) multivoxel spectroscopi
Post contrast 3D box reconstruction
After 8 weeks the patients are subject to another MRI-Scan in accordance with the standard
clinical guideline to rule out underlying pathology.
After 3 month the patients are seen in the outpatient-clinic to follow-up evaluation.
To sum up the purpose of this present study is to conduct a pilot investigation of MRI in
the early evaluation of ICH-patients. Second it is our intension to use multivoxel magnetic
resonance spectroscopy to study the metabolic penumbra-zone surrounding the ICH.
Observational Model: Cohort, Time Perspective: Prospective
Denmark: National Board of Health