Cardiometabolic Status in Childhood Acute Lymphoblastic Leukemia, A Pilot Study
This is a prospective cohort study with two groups: survivors of acute lymphoblastic
leukemia (ALL) who have recently completed therapy (cases) and healthy siblings (controls)
frequency matched by age and sex. Subjects in each group will have two visits. For cases,
the first visit will be approximately 6 months after completion of treatment for ALL; for
their siblings, the first visit occur at approximately the same time. For both cases and
controls, the second visit will be 2 to 2.5 years after the first visit.
Observational Model: Cohort, Time Perspective: Prospective
To determine the cardiometabolic profile (as measured by a single score based on adiposity, serum lipids, and vascular function) shortly after therapy (6 months after completion of therapy [Visit 1]) and again 2.5-3 yrs after completion of therapy (Visit 2) in 300 ALL patients, and compare with 200 sibling controls.
up to 2.5-3 Years
Julia Steinberger, MD, MS
Masonic Cancer Center, University of Minnesota
United States: Institutional Review Board