Intra-arterial Chemotherapy for the Treatment of Progressive Diffuse Intrinsic Pontine Gliomas (DIPG).
Delivering the chemotherapeutic agent directly to the tumor via the arterial system avoids
the complications and adverse events associated with toxicity from systemic chemotherapy.
Intervention Model: Single Group Assignment, Masking: Open Label
In this feasibility study, we are going to perform a qualitative evaluation of whether or not we can safely deliver IA chemotherapy to patients with progressive DIPG. Assessment of non-hematologic toxicity will include grading according to the Nervous system disorder CTCAE, specifically grades 3-5 intracranial hemorrhage and grades 3-5 stroke. Note will be made if the patient requires a blood transfusion.
Monica Pearl, M.D.
The Johns Hopkins Hospital
United States: Food and Drug Administration
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