Identification of Predictors of Tolerance to Chemoradiotherapy in Elderly Patients With Head and Neck Cancer
Purpose: To identify baseline predictors of change in function over the course of treatment
with chemoradiotherapy in patients with head and neck cancer.
Participants: Patients 65 or older who have an appointment at the North Carolina Cancer
Hospital (NCCH) or other participating sites, have planned chemoradiotherapy for head and
Procedures (methods): Consenting subjects will complete a Geriatric Assessment, Functional
Assessment of Cancer Therapy - Head and Neck and give a blood sample for CBC and p16INK4a
at the start of their chemoradiotherapy, at week four, at the end and 90 days post therapy.
They will also complete a health behavior questionnaire at baseline.
Time Perspective: Prospective
Significant Change in Function from Baseline to Post-Treatment
To determine if there is a significant change in the Instrumental Activities of Daily Living (IADL) subscore of the Geriatric Assessment (GA) from baseline to 90 days post-treatment.
Jared Weiss, MD
University of North Carolina
United States: Institutional Review Board
|UNC Lineberger Comprehensive Cancer Center||Chapel Hill, North Carolina|