Exercising Our ABC's (African- American Breast Cancer Survivors)
All exercise training will take place at the Gathering Place, Beachwood OH, in the new
Wellness Center that is equipped with state-of-the-art aerobic and resistance training
apparati. All exercise will be performed under the supervision of the Gathering Place
trained and certified staff. The patient group will perform a 20 week aerobic and resistance
exercise training program to evaluate (compared to baseline) changes: in body composition
(fat, lean tissue and bone mass); cytokines including insulin, leptin, adiponectin, IL-6,
and TNFα; oxidative stress including urine isoprostane; cardiorespiratory fitness (VO2max);
upper and lower body strength (assessed using a dynamometer); sleep (assessed using the
Pittsburgh Sleep Quality Index [PSQI]); fatigue and quality of life (Qol) (assessed using
the SF-36, FACIT instruments). Patients will be evaluated before and after a 20 week
intervention and a 10 week post-intervention period. Participants also will be evaluated
for motivation barriers and compliance. These feasibility parameters will provide the basis
and guidance for an NCI grant application to focus on mechanisms and extend our evaluation
to larger cohorts of African-American patients.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Identify factors contributing to or limiting the success of development of the community-academic partnership.
The primary endpoint is to determine if a successful partnership can be established between a community program, The Gathering Place, committed to providing support services to all community individuals with all types of cancer and academic researchers and clinicians at CWRU, Cleveland Clinic, UHCMC focused on modifying factors associated with energy balance to improve physical and psychological quality of life in cancer patients and provide the basis for future studies and programs to improve prognosis and survival.
Nathan Berger, MD
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
United States: Institutional Review Board
|Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center||Cleveland, Ohio 44106-5065|
|Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center||Cleveland, Ohio 44195|