The Clinical Trail Of NAFLD Treated By Traditional Chinese Medicine
1) Liver fat (measured by CT scan) and liver function assessed by liver enzymes levels; 2)
Insulin sensitivity measured by HOMA index, oral glucose tolerance test (OGTT) and a
euglycaemic hyperinsulinaemic clamp (with stable isotopes) in a subset of the subjects; 3)
Plasma lipid profile and non esterified fatty acids (NEFA) concentration; 4) Circulating
levels of adipokines.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
The CT ratio of liver/spleen
CT imaging has been used to assess hepatic steatosis and has been validated in relation to liver biopsy .The ratio of liver to spleen (L/S ratio) for CT attenuation values is an index, with a L/S ratio<1 considered to represent fatty liver .
Wen-Jian Wang, Ph.D,MD
Huashan Hospital, affliated to Fudan University
China: Food and Drug Administration