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Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood & Urine Monitoring Study of Liver Transplant Recipients


N/A
18 Years
N/A
Not Enrolling
Both
Proteogenomic Monitoring in Liver Transplant Recipients

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Trial Information

Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood & Urine Monitoring Study of Liver Transplant Recipients


Inclusion Criteria:



- Subjects undergoing primary deceased-donor or living donor liver transplantation.

- Subject must be able to understand and provide informed consent.

Exclusion Criteria:

- Need for combined organ transplantation

- Previous solid organ and/or islet cell transplantation

- Infection with HIV

- Allergy to Iodine

- Inability or unwillingness of a participant to comply with study protocol

- Any condition that, in the opinion of the investigator, would interfere with the
participant's ability to comply with study requirements

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Acute Rejection

Outcome Description:

The primary endpoint is the incidence of biopsy proven AR at 3, 12 and 24 months after LT.

Outcome Time Frame:

3 months after liver transplant

Safety Issue:

Yes

Principal Investigator

Josh Levitsky, MD, MS

Investigator Role:

Study Chair

Investigator Affiliation:

Northwestern Univ.

Authority:

United States: Federal Government

Study ID:

DAIT CTOT-14

NCT ID:

NCT01672164

Start Date:

August 2012

Completion Date:

August 2015

Related Keywords:

  • Proteogenomic Monitoring in Liver Transplant Recipients
  • liver transplantation

Name

Location

Cleveland Clinic FoundationCleveland, Ohio  44195
Medical University of South CarolinaCharleston, South Carolina  29425-0721
Baylor University Medical CenterDallas, Texas  75246
Mayo ClinicScottsdale, Arizona  
Northwestern University, Feinberg School of MedicineChicago, Illinois  60611
Scripps Center for Organ and Cell TransplantationLa Jolla, California  92037