Inclusion Criteria:

- Males and females

- Age 18-75 years old with informed consent

- Patients with IgG4-RD:

1. swelling, sclerosing and inflammatory involvement of one or more organ,
including sclerosing pancreatitis, sclerosing cholangitis, inflammatory
pseudotumors, retroperitoneal or mediastinal fibrosis, interstitial nephritis,
hypophysitis, sclerosing dacryoadenitis, sialadenitis, inflammatory aortic
aneurysm, lymphadenopathy, or other inflammatory conditions;

2. elevated serum IgG4 (>1.35 g/L)

3. histopathologic features of fibrosis and/or lymphocytic and polyclonal plasma
cell infiltration (and IgG4+ plasma cells on immunohistology when performed);

4. exclusion of other diseases.

Exclusion Criteria:

- Females planning to bear a child recently or with childbearing potential

- Concurrent severe and/or uncontrolled and/or unstable diseases

- Patient with malignancy