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Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles


Phase 4
20 Years
39 Years
Not Enrolling
Female
Endometrial Preparation, Frozen Embryo Transfer

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Trial Information

Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles


Inclusion Criteria:



- women > 40 years old,

- history of endocrine disease

- Hysteroscopic surgery

- cardiovascular, renal and liver disease

- hypotension( blood pressure < 90/50)

- history of stroke or myocardial infarction

- use of alcohol or substance

Exclusion Criteria:

A total of 80 patients with antecedent of poor endometrial response and had
frozen embryo included in this study all women must to be < 40 years old,

- no history of endocrine disease,

- no Hysteroscopic surgery, had a high quality embryos no cardiovascular,

- renal and liver disease and

- no hypotension (blood pressure < 90/50) or

- history of stroke or myocardial infarction and

- don't use of alcohol or substance Patients with these conditions enter this
study and based on randomized tables are divided in two groups.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

estimate the result of sildenafil on ultrasonographic endometrial thickness

Outcome Description:

Assays: Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred.

Outcome Time Frame:

between 2009-2011 (up to 2 years)

Safety Issue:

Yes

Principal Investigator

farzaneh hojjat, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Science, Bouali Ave. Safaieh, Yazd,Iran.

Authority:

United States: Food and Drug Administration

Study ID:

radvin123

NCT ID:

NCT01668446

Start Date:

September 2009

Completion Date:

February 2011

Related Keywords:

  • Endometrial Preparation
  • Frozen Embryo Transfer
  • Sildenafil
  • Endometrial thickness
  • Frozen embryo transfer
  • ultrasonographic endometrial thickness
  • endometrial pattern
  • Implantation rate
  • chemical pregnancy rate
  • Adenoma

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