Detection of Benign and Malignant Thyroid and Breast Tumors by Fourier Transform Infrared Spectrometry
Recently,the methods to the diagnosis of tumors include palpation,X-ray,ultrasound,CT and
MRI.The doctors could not get conclusion without a existing mass.The FNB is very popular
nowadays in western countries,but it has been reported that about one-third malignant cases
have been neglected by FNB,for the tissue isn't enough through the needle.There also have
been reports about the increased auxilliary lymphnode metastases for breast cancer because
of FNB.Although the Mammotome has been used widely,it is still traumatic.
Process of malignant transformation of tissues and cells, first proteins, lipids,
carbohydrates and nucleic acids constitute the main substance of tissue and cell structure,
conformation, and the number of occurrence of significant changes in subsequent histological
changes. Fourier transform infrared spectroscopy is the major molecular bond coupling
between the atoms vibrational spectra and molecular rotational spectra.
In this study, consists of three phases:
Continuous enrollment requires inpatient surgery 300 cases of thyroid cancer patients and
breast cancer patients, 200 cases of preoperative determination of tumor on the surface
infrared spectroscopy, infrared spectroscopy of the anterior tumor tissue and lymph node
surgery, measured in vivo; at the same time into the group of 50 patients healthy people,
the determination of surface infrared spectroscopy of the thyroid and breast area. Paraffin
pathological findings as the gold standard, the thyroid and breast cancer patients were
divided into the benign group and malignant group, relatively healthy and good, the
distribution of differences of the surface infrared spectrum of malignant group, while
relatively good in the malignant group IR spectra of the distribution of differences.
Were enrolled, infrared spectroscopy and pathological specimens were collected at different
stages. Paraffin pathological findings as the gold standard, were established two tumor
surface, the infrared spectra of the fresh in vitro and in vivo for tumor benign or
malignant diagnosis discrimination system.
Into the infrared spectra collected data on behalf of the above-mentioned discrimination
system to verify its sensitivity, specificity and accuracy; both paraffin pathological
findings as the gold standard to compare the infrared spectral discrimination systems and
intraoperative frozen section pathology for the diagnosis of benign and malignant tumors
correctly rate differences, to explore the clinical value of infrared spectroscopy
Time Perspective: Cross-Sectional
In operation patients, discriminant between benign and malignant thyroid and breast tumors are established by fourier transform infrared spectrometry variables, and pathologic diagnoses are gold standard. Between Patients and healthy volunteers, discriminant are established among thyroid and breast tumors and healthy tissues.
Zhi Xu, PhD MD
Peking University Third Hospital
China: Ethics Committee