Prehabilitation to Enhance Postoperative Functional Capacity Following Esophageal Resection
A randomized controlled study in patients undergoing esophageal resection for cancer to
determine the impact of multimodal prehabilitation on functional exercise capacity and
postoperative pulmonary complications. Patients who accept to be enrolled in the study will
be randomized to receive either a standard nutritional intervention (including supplements
as needed) as per current institution policy or standard nutritional intervention (including
supplements as needed) combined with a physical exercise program before and after surgery.
The aims of this research project are the following:
1. To determine the extent in which a multimodal prehabilitation regimen optimizes
functional recovery in patients suffering from esophageal cancer and the incidence of
postoperative pulmonary complications.
2. To understand further which measures of immediate surgical recovery are sensitive to
prehabilitation interventions, and predict change in later outcome measures.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research
6 minute walk test (6MWT)
The 6MWT evaluates the ability of an individual to maintain a moderate level of physical activity over a time period reflective of the activities of daily living. Subjects are instructed to walk back and forth, in a 20 m stretch of hallway, for six minutes, at a pace that would make them tired by the end of the walk; encouragement and feedback are given according to published guidelines.
up to 8 weeks after surgery
Franco Carli, M.D.
Montreal University Health Centre
Canada: Ethics Review Committee