Usefulness of Myocardial Deformation Imaging in Breast Cancer Patients Treated With Trastuzumab for Early Detection of Myocardial Dysfunction
The investigators will prospectively evaluate whether changes in tissue deformation,
assessed by myocardial strain and strain rate (SR) and identify possibility of early
detection of LV dysfunction in patients treated with trastuzumab.
Observational
Observational Model: Case-Only, Time Perspective: Prospective
LV systolic dysfunction
LV systolic dysfunction was defined as following; An EF unit drop of ≥10% from the baseline available echocardiogram or Change in strain or strain rate : drop(decrement) corresponding to ≥1 SD of the relevant parameter assessed at the baseline available echocardiogram
3-month F/U
No
Hyung-Kwan Kim, M.D., PhD
Principal Investigator
Seoul National University Hospital
Korea: Food and Drug Administration
H1106-026-365
NCT01665300
July 2011
December 2013
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