Inclusion Criteria:

Age range 14-70 years old; ECOG performance status 0-2; Estimated survival time > 3 months
Histological confirmed Peripheral T cell lymphoma None of chemotherapy or radiotherapy has
been previously used None of chemotherapy contraindication: hemoglobin ≥ 90 g/dl,
neutrophil ≥ 1.5×109/L, platelet ≥ 100×109/L, ALT and AST ≤ 2×ULN, serum bilirubin ≤
1.5×ULN, serum creatine ≤ 1.5×upper limitation of normal (ULN), Serum Albumin ≥ 30g/L,
serum plasminogen is normal (Inclusion Criteria of 1,3,6 groups ) At least one measurable
lesion None of other serious diseases, cardiopulmonary function is normal Pregnancy test
of women at reproductive age must be negative Patients could be followed up None of other
relative treatments including the traditional Chinese medicine, immunotherapy,biotherapy
except anti-bone metastasis therapy and other symptomatic treatments.

volunteers who signed informed consent.

Exclusion Criteria:

Disagreement on blood sample collection Patients allergic of any of drug in this regimen
or with metabolic disorder Pregnant or lactating women Serious medical illness likely to
interfere with participation Serious infection Primitive or secondary tumors of central
nervous system Chemotherapy or radiotherapy contraindication The evidence of CNS
metastasis History of peripheral nervous disorder or dysphrenia patients participating in
other clinical trials patients taking other antitumor drugs patients estimated to be
unsuitable by investigato