A Clinical Trial to Develop Chest Imaging, Breath, and Biomarkers in a Screening Trial
The fight against lung cancer is waged on three major fronts: prevention, detection and
treatment. Our goal is to determine if chest x-rays,computer aided detection (CAD)and a CT
scan can detect disease earlier when treatment is more effective. If we improve the
detection of disease, we will see if screening reduces the incidence of symptomatic advanced
lung cancer relative to no screening in people at high risk to develop lung cancer.
Observational Model: Cohort, Time Perspective: Prospective
The sensitivities of chest x-ray with CAD and chest CT
The false positive rates of chest x-ray with CAD and chest CT will be compared. The analysis will be based on the study subjects from this prospective study who test positive with chest x-ray and/or CT and who are determined not to have lung cancer during the follow-up period.
March, 2012 for scanning results only
Micheal Phillips, M.D.
The Cleveland Clinic
United States: Institutional Review Board
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