Inclusion Criteria:

- rectal cancer patients

- neoadjuvant chemoradiation therapy (+)

- sphincter saving surgery with total mesorectal excision (+)

- temporary loop stoma (+)

- adult who is 17 years or older

- patinet who aggree with our study

- if woman is childbearing age, her pregnancy test shoud be indentified 'negative'

Exclusion Criteria:

- patients who have been enrolled to other clinical studies related to this study

- patients who underwent diverting stoma before neoadjuvant chemoradiation

- temporary end -ostomy (+)

- uncontrolled metabolic or systemic disease

- patients who do not understand the purpose of this study because of dementia or
pshycologic problem

- MRSA or Clostridium difficille (+)

- Pregnant or during breast feeding

- serious complication after sphincter saving surgery