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Study of the Prevalence of Colorectal Cancer in Patients With Nonalcoholic Fatty Liver Disease.

10 Years
Not Enrolling
Colorectal Neoplasms, Nonalcoholic Fatty Liver Disease

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Trial Information

Study of the Prevalence of Colorectal Cancer in Patients With Nonalcoholic Fatty Liver Disease.

As one of the most common cancer worldwide, colorectal cancer (CRC) is a major cause of
cancer death in Asian countries. And during the past three decades, the incidence of CRC has
been increasing rapidly in china. Many studies supported that cigarette smoking, obesity and
insulin resistance were associated with CRC. In recent years, metabolic syndrome (MetS)
- Including glucose tolerance, dyslipidemia, obesity, hypertension and chronic inflammation -
and its individual components have been proven to be the risk for colorectal neoplasm.
Colonoscopy is the most accurate technique for diagnosis, surveillance and exclusion of
colorectal neoplasm for high-risk CRC groups. Therefore, improved risk stratification
knowledge of the target population is necessary to improve CRC patients' prognosis.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease
worldwide and cause a wide spectrum of liver damage, such as steatohepatitis, cirrhosis,
even end-stage liver disease and hepatocellular carcinoma. NAFLD has been found to be
associated with obesity, insulin resistance, hypertension and dyslipidemia, and is
considered as a liver manifestation of MetS. Although it has been also well established that
MetS and its individual components are risk factors for colorectal neoplasm, as above, there
is paucity of research looking at the relation between NAFLD and CRC. Therefore, the
investigators aimed to investigate the prevalence of CRC in patients with NAFLD and evaluate
whether NAFLD is an independent risk factor for CRC.

Inclusion Criteria:

- Patients had colonoscopy and

- Patients had conventional inspections(blood routine, liver function test and abdomen
B ultrasonography)

Exclusion Criteria:

- Patients were excluded with history of colorectal cancers or polyps, other
extraintestinal malignancies and contraindications to colonoscopy.

- Patients were excluded who had viral hepatitis, cirrhosis, liver cancer or other
liver disease.

- Patients ere excluded who drank more than 20g alcohol per day.

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Ultrasound examination

Outcome Description:

Hepatic ultrasonography scanning was performed on all patients by experienced radiologists who were blinded to the aims of the study and clinical details of the patients. NAFLD was diagnosed by the following criterion: hepatomegaly, the echogenicity of liver parenchyma increased diffusely, and vascular blurring.

Outcome Time Frame:

Up to 10 months

Safety Issue:


Principal Investigator

MingHua Zheng, Medical Master

Investigator Role:

Study Chair

Investigator Affiliation:

First Affiliated Hospital of Wenzhou Medical College


China: Ethics Committee

Study ID:

wenzhouMC 001



Start Date:

April 2012

Completion Date:

July 2012

Related Keywords:

  • Colorectal Neoplasms
  • Nonalcoholic Fatty Liver Disease
  • Neoplasms
  • Colorectal Neoplasms
  • Fatty Liver
  • Liver Diseases