Inclusion Criteria:

1. Karnofsky≥70

2. Provision of informed consent

3. Pathological confirmation of breast cancer

4. Hormone receptor-positive and accept aromatase inhibitors for adjuvant endocrine
therapy

5. Not previously received treatment with bisphosphonate

6. Laboratory criteria:

PLT≥100*109/L WBC≥4000/mm3 HGB≥10g/dl GOT,GPT,ALP≤2*ULN TBIL,DBIL,CCr≤1.5*ULN

7. Surgery , radiotherapy and chemotherapy has finished

Exclusion Criteria:

1. Pregnant of lactation woman

2. History of organ transplantation

3. With mental disease

4. With severe infection or active gastrointestinal ulcers

5. With severe liver disease (such as cirrhosis), kidney disease, respiratory disease or
diabetes

6. Disease-free period of other malignant tumor is less than 5 years(except cured basal
cell skin cancer and cervical carcinoma in situ)

7. With heart disease

8. Experimental drug allergy