Inclusion Criteria:

- postmenopausal HR positive breast cancer patients;

- inoperable locally advanced or metastatic breast cancer patients;

- candidate for endocrine therapy;

- ECOG equal to or less than 1;

- adequate bone marrow function(Hb>=90g/L, WBC >=3.5×10^9/L,ANC>=1.5×10^9/L,
PLT>=80×10^9/L; adequate renal function(Ccr<=ULN);adequate liver
function(ALT,AST,AKP<=2.5*ULN,or <=5*ULN if liver metastases)

- life expectancy >=12weeks;

- no severe history disease of liver,heart,lung or kidney;

- written informed consent form;

Exclusion Criteria:

- Her-2 overexpression;

- patients who has visceral endocrisis；