Evaluation of Half-Dose Molecular Breast Imaging With Wide Beam Reconstruction Processing
Recent implementation of dose reduction strategies for Molecular Breast Imaging now allow
performance of MBI at an administered dose of 8 mCi Tc-99m sestamibi, which is reduced from
the previously used doses of 20-30 mCi. In order to safely introduce MBI as a screening
modality, we aim to perform MBI using 4 mCi Tc-99m sestamibi. An image processing algorithm
called Wide Beam Reconstruction (WBR) has been tailored for MBI technology with the goal of
allowing either the current administered dose or current acquisition time to be reduced by
Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor)
Compare the diagnostic accuracy (sensitivity, specificity, PPV, NPV, LR(T+), LR(T-), diagnostic OR, AUC/concordance) of 8 mCi molecular breast imaging (MBI), 4 mCi MBI, and 4 mCi MBI with Wide Beam Reconstruction (WBR).
A timely clinical interpretation will be performed of the 8 mCi MBI. A new finding on MBI will be worked up according to the established standard of care. Following collection of all study MBIs, three study radiologists will provide a blinded interpretation of the following three acquisition settings for each patient: 8 mCi MBI, 4 mCi MBI, and 4 mCi MBI with WBR processing applied. The acquisitions will be anonymized and presented in randomized order at three separate reading sessions with 4-6 weeks between each session.
At time of study (within 2 days after exam) and when enrollment has been reached (approximately 24 months)
Carrie B Hruska, PhD RD
United States: Institutional Review Board
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