Inclusion Criteria:

- Patients with known or suspected prostate disease based on clinical data will be
included in the study; patients with intermediate to high grade prostate cancer
(Gleason's score >= 7 and prostate-specific antigen [PSA] of > 10ng/dl) will be
referred from the outpatient clinics after evaluation by the treating physicians

- Written informed consent will be signed by the patients before the MRI based on the
guidelines approved by the Ohio State University Institutional Review board

- Patients must have an estimated glomerular filtration rate of >= 30 mL/min/1.73m^2
within six weeks of the MRI to be included in the study

Exclusion Criteria:

- Patients with any type of bioimplant activated by mechanical, electronic, or magnetic
means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators,
electronic infusion pumps, etc.)

- Patients with any type of ferromagnetic bioimplant that could potentially be
displaced or damaged

- Patients that have vascular or aneurysm clips, or metallic staples from a surgical
procedure

- Patients with permanent tattoo eye liner (may contain metallic coloring)

- Patients that may have shrapnel imbedded in their bodies, such as from war wounds,
metal workers and machinists (metallic fragments in or near eyes), severe auto
accident victims

- Patients that exhibit noticeable anxiety and/or claustrophobia

- Patients who cannot adhere to the experimental protocols for any reason, or have an
inability to communicate with the researcher

- Patients who have cardiac or known circulatory impairment, and/or the inability to
perspire (poor thermoregulatory function)

- Patients with an estimated glomerular filtration rate of < 30 mL/min/1.73m^2 within
six weeks of the MRI

- Acute or chronic severe renal insufficiency (estimated glomerular filtration rate <
30 mL/min/1.73m^2)

- Acute renal dysfunction due to the hepato-renal syndrome or in the perioperative
liver transplantation period