Imaging of the Prostate Gland Using High Field Strength 3T MRI
I. To assess the impact of prostate MRI, without an endorectal coil, done at 3-Tesla on
surgical management. This would be performed by examining the agreement of lesion location
based on the MRI compared to the lesion location based on pathology and/or surgery and local
extent of the disease, i.e. involvement of contiguous organs and local lymph nodes, based on
the MRI compared to the local extent based on pathology and/or surgery.
II. To test the reproducibility of functional MRI (dynamic-contrast enhanced [DCE_MRI] MRI,
magnetic resonance [MR] spectroscopy and diffusion-weighted MRI).
I. To assess the usefulness of MRI data in treatment planning for radiation therapy, and to
test the feasibility of amide-proton-transfer MRI in prostate cancer detection.
II. To evaluate MRI changes in prostate and tumor morphology between endorectal coil versus
no endorectal coil.
III. To assess the usefulness of ex-vivo prostate specimen MRI for accurate co-registration
between in-vivo MRI of the prostate and pathology slides.
Patients undergo 3-tesla (3T) MRI, including DCE-MRI, diffusion-weighted MRI,
amide-proton-transfer MRI, and MR spectroscopy scans. Patients may undergo an additional 3T
MRI scan at least 24 hours after the initial scan.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Diagnostic imaging quality of the prostate at 3T high field imaging without an endorectal coil
Up to 6 years
Michael Knopp, MD
Ohio State University
United States: Institutional Review Board
|The Ohio State University Medical Center, Stress||Columbus, Ohio 43210|