Study of S1 Efficacy and Toxicity as Second-line Treatment on Inoperable or Advanced Gastric Cancers
TS, DPD and OPRT are the key enzymes on the metabolic pathway of 5-Fu. We will
retrospectively analyze the clinicopathological features of the patients who have suffered
an inoperative or recurrent gastric cancers and administrated with S-1, such as the overall
survival (OS), progressive-free survival (PFS), Lauren's classification and toxicity of S1,
etc. We will divide the patients into several subgroups according to the parameters above,
and then investigate the correlation between the parameters and the expression of TS, DPD
All of the analysis is retrospective, there is no different treatment operation once the
subject enrolled in this study.
Observational Model: Case-Only, Time Perspective: Prospective
Xu Jianming, M.D.
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
China: Ethics Committee