Phase I Study of Role of Stem Cells in Improving Implantation Rates in ICSI Patients
- ICSI candidates with repeated implantation failure and history of development of good
embryos in previous ICSI cycles.
- Advanced maternal age above 38 years.
- Poor endometrial response to ovulation induction drugs.
- Endometrial atrophy.
- Presence of infection in the form of vaginitis, cervicitis or hydrosalpinx.
- Presence of uterine abnormality as uterine septum.
- Presence of any pathology distorting the uterine cavity as:
submucus polyp or submucus myoma.
- Marked sperm morphology abnormality.
- High FSH > 12 IU.
Type of Study:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Comparison of the implantation rates of all groups; the differentiated stem cell group, the undifferentiated stem cell group and the control group to assess the efficacy of differentiated and undifferentiated stem cell therapy in improving endometrial receptivity.
Outcome Time Frame:
Nawara Mohamed Hashish, MD
Assistant Professor of Gynecology and Obstetrics
Egypt: Ministry of Health and Population
Stem cells and implantation
- Assess the Efficacy of Differentiated and Undifferentiated Stem Cell Therapy in Improving Endometrial Receptivity.
- Stem cells
- Uterine cavity