Inclusion Criteria:

1. Karnofsky ≥ 70

2. Provision of informed consent

3. Pathological confirmation of breast cancer

4. Tumor stage (TNM):T2-4bN0-3M0

5. Measurable disease as per RECIST criteria

6. Not previously treated with radiotherapy, chemotherapy or biological therapy.

7. Laboratory criteria:

- PLT ≥ 100*109/L

- WBC ≥ 4000/mm3

- HGB ≥ 10g/dl

- GOT,GPT,ALP ≤ 2*ULN

- TBIL,DBIL,CCr ≤ 1.5*ULN

Exclusion Criteria:

1. Pregnant woman

2. History of organ transplantation

3. With mental disease

4. With severe infection or active gastrointestinal ulcers

5. With severe liver disease (such as cirrhosis), kidney disease, respiratory disease or
diabetes

6. Disease-free period of other malignant tumor is less than 5 years (except cured basal
cell skin cancer and cervical carcinoma in situ)

7. With heart disease

8. Experimental drug allergy