Know Cancer

forgot password

Shrinking Target Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer

18 Years
Open (Enrolling)
Non Small Cell Lung Cancer

Thank you

Trial Information

Shrinking Target Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer

Inclusion Criteria:

- Age 18 or older

- Willing to provide informed consent

- ECOG performance status 0-2

- Histologically confirmed non-small cell lung carcinoma

- Locally advanced stage IIIA or IIIB lung carcinoma according to AJCC 7th edition

- Expected lung V20 of 35-60%, as determined at the time of 4D-CT simulation

- Assessment by medical oncologist and radiation oncologist, with adequate hepatic and
renal function for administration of cisplatin-based doublet chemotherapy, at the
discretion of the medical oncologist

Exclusion Criteria:

- Serious medical comorbidities or other contraindications to radiotherapy or

- Prior history of lung cancer within 5 years

- Prior thoracic radiation at any time

- Metastatic disease

- in some select cases, patients with a solitary metastasis (i.e. brain metastasis) may
receive radical chemoradiotherapy after resection/ablation of their metastatic
lesion, as standard practice. In such cases, the patient may be enrolled onto this
study at the discretion of the local principle investigator once the metastasis has
been treated.

- inability to attend full course of radiotherapy of follow-up visits

- Pregnant or lactating women

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Tumor reduction

Outcome Time Frame:

2.5 years (end of treatment)

Safety Issue:


Principal Investigator

David Palma, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

London Regional Cancer Program of the Lawson Health Research Institute


Canada: Ethics Review Committee

Study ID:




Start Date:

January 2013

Completion Date:

December 2014

Related Keywords:

  • Non Small Cell Lung Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms