The Effect of Perioperative Epidural Opioids on Inflammatory Cytokines and Immune Function
We will consider for inclusion any adult patient undergoing a planned curative hepatic
resection of a colorectal carcinoma liver recurrence.
E 3. Patients Excluded Any patient unable to communicate in English or French. Any patient
with evidence of extra-hepatic metastasis. Any patient with contra-indications to epidural
anesthesia, or any of the medications used in the study.
Any patient with evidence of coronary artery disease or congestive heart failure, either
previously or currently.
Any patient with insulin treated diabetes. Any patient with a BMI greater than 40. Any
patient who has received steroids in the past 2 months. Any patient who has taken any pain
medication the week before surgery. Any pregnant or breast feeding patient. Any patient
with a chronic inflammatory disease, including but not limited to Lupus, rheumatoid
arthritis, and inflammatory bowel disease.