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Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor

25 Years
60 Years
Not Enrolling
Brain Neoplasms, Surgery, Hyperemia

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Trial Information

Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor

30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain
tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery
group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral
artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb
(SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be
measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after
extubation in both groups.

Inclusion Criteria:

- American Society of Anesthesia (ASA) physical status I or II

- Scheduled for selective supratentorial tumor removal surgery or major abdominal

Exclusion Criteria:

- Patients with evidence of systemic hypertension, intracranial hypertension,
cerebrovascular diseases, other coexisting medical conditions likely to affect
cerebral autoregulation.

- Preoperatively planned delayed tracheal extubation.

- Pregnant or nursing women

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

Mean Blood Flow Velocity in Middle Cerebral Artery

Outcome Description:

It was the baseline mean blood flow velocity in middle cerebral artery.

Outcome Time Frame:

before general anesthesia

Safety Issue:


Principal Investigator

Xiao-Yu Yang, Master

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fudan University


China: Science and Technology Commission of Shanghai Municipality

Study ID:




Start Date:

November 2012

Completion Date:

January 2013

Related Keywords:

  • Brain Neoplasms
  • Surgery
  • Hyperemia
  • Cerebral blood flow
  • Transcranial Doppler
  • Emergence from general anesthesia
  • Brain Neoplasms
  • Neoplasms
  • Hyperemia