Inclusion Criteria:

1. Patients with HCV-positive HCC who meet the following conditions before radical
treatment

- Patients diagnosed as having typical HCC on dynamic CT,CTA/CTAP, or dynamic MRI
(nodule visualized as a high signal intensity area in the arterial phase and as
a relatively low signal intensity area in the portal and equilibrium phases)
performed within 8 weeks (56 days) before treatment start prior to radical
therapy

- Patients with the first primary HCC or the first recurrence of primary HCC

2. Patients who received the radical therapies. The treatment duration (from the start
to the end of the treatment) should be within 4 weeks (28 days) for each of the
radical therapies.

3. Patients showing a complete cure, as confirmed by the dynamic CT images taken from 8
weeks (56 days) to 12 weeks (84 days) after the end of the treatment show a
non-stained low-concentration area overlapping the tumor image observed before
complete cure.

4. Patients who are able to begin treatment with the study drug within 8 weeks (56 days)
after dynamic CT to confirm complete cure

5. Patients confirmed of satisfying the following conditions based on the screening
performed at subject registration

- Positive for serum hepatitis C virus nucleic acid (HCV-RNA)

- Grade A on Child-Pugh classification

- Platelet count of 50 000/µL or higher

6. Patients with ECOG Performance Status score of 0 to 1

7. Patients of the age of 20 years or older at the time of informed consent

Exclusion Criteria:

1. Patients positive for HBs antigen

2. Patients showing vascular invasion of HCC on imaging diagnosis

3. Patients who have also undergone transcatheter arterial embolization therapy
(TAE/TACE), transarterial infusion therapy (TAI), and chemolipiodolization in
combination with the radical therapy

4. Patients who want to receive antiviral therapy such as interferon during the study
period

5. Patients who have received other study drugs, anticancer drugs, or interferons after
radical therapy

6. Patients who have hypertension as a complication, and whose blood pressure cannot be
controlled by drug therapy (systolic blood pressure of 160 mmHg or higher or
diastolic blood pressure of 100 mmHg or higher, as determined at subject
registration)

7. Patients who have a history of allergy to CT contrast media, and whose participation
in this study is judged to be inappropriate by the investigator or the
subinvestigator

8. Patients with a history of total gastrectomy

9. Patients with a history of cardiac arrest

10. Patients with any of the following laboratory values or complications

- Creatinine>= 1.5mg/dL

- Albumin urine >= 1000mg/g Creatinine

- Cardiac disorder corresponding to CTC-AE grade 3 in severity

- HbA1c >= 7.4 under treatment with insulin

- Autoimmune disease or asthma being treated with oral steroid

11. Patients confirmed of having another malignant neoplasm or who had undergone a
radical therapy of HCC within the past 5 years to treat another malignant neoplasm
(however, this does not apply to endoscopic resection and resection of
intraepithelial carcinoma)

12. Patients who are pregnant, who have a possibility of being pregnant or who have a
desire to become pregnant during the study period

13. Lactating women

14. Patients who have a history of allergy to retinoid-related substances (vitamin A,
etc.) in the past

15. Patients who participated in another clinical study within past 6 months